We are looking for a highly motivated PhD candidate to investigate how chemotherapy shapes the genomes of normal pediatric tissues and why some cells are more resilient to treatment-induced DNA damage than others. Building on discoveries from our group, you will study the molecular pathways that determine susceptibility to chemotherapy-induced mutagenesis. You will combine single-cell whole-genome sequencing with experimental model systems, such as organoid cultures, and functional perturbation approaches to identify mechanisms that protect normal tissues from acquiring permanent genetic damage. While much of our previous work focused on the hematopoietic system, this project will extend these studies to tissues that are strongly affected by late effects, including the heart and brain. By integrating experimental and computational analyses, you will generate fundamental insights into how childhood cancer therapy influences lifelong tissue health with the goal to identify potential avenues to reduce long-term treatment toxicity. You will work in a multidisciplinary team of molecular biologists, computational scientists, and clinician-scientists in a collaborative, international research environment at the Princess Máxima Center.

About Us

Our research group combines cutting-edge molecular biology with advanced genomics to investigate cancer etiology, disease mechanisms, and the long-term consequences of cancer treatment. By developing and applying state-of-the-art single-cell genomics technologies, we study how somatic mutations arise, how they shape human tissues throughout life, and how they contribute to cancer and aging. Survival rates for children with cancer have improved dramatically over the past decades. However, understanding the long-term effects of cancer and its treatment remains an important area of research. Our lab uses unique patient materials, single-cell whole-genome and transcriptome sequencing, functional genomics, and computational approaches to uncover the molecular mechanisms underlying carcinogenesis, disease progression, and treatment-induced mutagenesis.

Your Qualifications

• MSc degree in Molecular Biology, Biomedical Sciences, Genetics, Cancer Biology, Bioinformatics, or a related field
• Motivation to pursue an academic career
• Strong interest in bioinformatics, cancer biology, genomics, DNA damage and repair, or stem cell biology
• Experience with computational biology and genomics is an advantage, but enthusiasm to learn new techniques is equally important
• Excellent analytical, organizational, and communication skills
• Ability to work independently as well as collaboratively within an interdisciplinary team
• Excellent command of spoken and written English

Our Job Offer

A temporary, full-time PhD position for a total duration of 4 years (36 hours/week), in an internationally recognized research institute. You will have access to state-of-the-art single-cell genomics technologies and research facilities and work in a collaborative and supportive research environment with close supervision and extensive opportunities for professional development. You will also have opportunities to present your work at international conferences and collaborate with leading researchers worldwide. You will initially be contracted for a period of 1 year, after which your performance will be evaluated, and the contract may be extended for the remaining years. The Princess Máxima Center operates according to the collective labor agreement ‘cao algemene ziekenhuizen’. Your gross monthly salary will be €3.813,- gross a month for a full-time working week (36 hours, FWG 45-6) and will include an 8.33% gross monthly salary holiday allowance and an 8.33% end-of-year bonus.

The Princess Máxima Center

The Princess Máxima Center for Pediatric Oncology is an integrated hospital and research institute, which integrates healthcare, research, and education on pediatric cancer in a single location in Utrecht. Our institute aims to provide the highest level of care for all children with cancer, with optimal quality of life. The center brings together the best possible care and scientific research, creating a unique interdisciplinary institute for pediatric oncology in Europe.